HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2070849Generated: October 26, 2026
Trifluoroacetic acid → methyl 4-chloro-3-(2,3-dioxo-3,4-dihydropyrazin-1(2H)-yl)benzoate
https://huagongshe.com/reaction/2070849
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Methyl 4-chloro-3-{[[(2,2-dimethoxyethyl)amino](oxo)acetyl]amino}benzoate | HCID 66688946 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | methyl 4-chloro-3-(2,3-dioxo-3,4-dihydropyrazin-1(2H)-yl)benzoate | HCID 66690376 | 115.6% |
Reaction Steps
A suspension of methyl 4-chloro-3-{[[(2,2-dimethoxyethyl)amino](oxo)acetyl]amino}benzoate (Example 330c, 8.5 g) in acetic acid (26 mL) was treated with trifluoroacetic acid (8.5 mL) under nitrogen. The resulting mixture was stirred at 120° C. for 3 h. The mixture was quenched with water (20 mL) and the resulting solid filtered off to give the subtitle compound (8.00 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08299246B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-7aa11dac019b4237b53620a523de41eb |
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| Source note | uspto-grants-2012_10 |
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