4-Nitro-o-toluic acid → HCID 86640812, compound

HRID 2070863Notes

Reaction equation

HRID 2070863 reaction equation
N[C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][N:7]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[C:8]2=[O:11])=[CH:4][CH:3]=1.CC1C=C([N+:29]([O-])=O)C=CC=1C(O)=O>>[NH2:29][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:2]=1)[C:8](=[O:11])[N:7]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:6]2

Participants

3

Reactant 2

HCID 747904-Nitro-o-toluic acidHCID 67293474HCID 67293474, compound

Product 1

HCID 86640812HCID 86640812, compound

Procedure

tert-Butyl 5-amino-1-oxoisoindoline-2-carboxylate was prepared following the same procedure used for the preparation of tert-butyl 6-amino-1-oxoisoindoline-2-carboxylate using 2-methyl-4-nitrobenzoic acid as starting material.

Sources & evidence

ORD record
ord-e821800088d141c8891625fb125c0fff
Source dataset
uspto-grants-2012_10
Patent number
US08299056B2

Reaction notes

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