HCID 68588481, compound → 1H-benzimidazole-2-carbonitrile

HRID 2070894Notes

Reaction equation

HRID 2070894 reaction equation
FC(F)(F)C1C=CC(NC2N=C3C=CC=C([C:18]4[CH:19]=[CH:20][C:21]5[N:25]=[C:24]([C:26]#[N:27])[NH:23][C:22]=5[CH:28]=4)N3N=2)=CC=1>N>[NH:23]1[C:22]2[CH:28]=[CH:18][CH:19]=[CH:20][C:21]=2[N:25]=[C:24]1[C:26]#[N:27]

Participants

3

Reactant 1

HCID 68588481HCID 68588481, compound

Product 1

HCID 8438581H-benzimidazole-2-carbonitrileYield 96.1%

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

6-(2-(4-(Trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazole-2-carbonitrile. A solution of 5-(2-(trichloromethyl)-1H-benzo[d]imidazol-6-yl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-c]pyridin-2-amine (380 mg, 0.745 mmol) in methanolic ammonia solution (20 mL) was stirred at 0° C. to room temperature for 2 h. The solvent was removed under reduced pressure to give crude 64244-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-c]pyridin-5-yl)-1H-benzo[d]imidazole-2-carbonitrile (300 mg, 96.1% yield). MS (ESI): m/z 420.1 [M+1]+.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-98dab3010a614f098ee4ec9c92d77a92
Source dataset
uspto-grants-2012_10
Patent number
US08299056B2

Reaction notes

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