Methyl 2-methylnicotinate → Methyl 6-cyano-2-methylnicotinate

HRID 2070928Notes

Reaction equation

HRID 2070928 reaction equation
[CH3:1][C:2]1[N:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].C(C1C=C[N:18]=[C:17](CN)C=1)(C)C>>[C:17]([C:10]1[CH:9]=[CH:8][C:3]([C:4]([O:6][CH3:7])=[O:5])=[C:2]([CH3:1])[N:11]=1)#[N:18]

Participants

3

Reactant 2

HCID 7015327Methyl 2-methylnicotinateHCID 59135389(4-Isopropylpyridin-2-yl)methanamine

Product 1

HCID 55253164Methyl 6-cyano-2-methylnicotinate

Procedure

methyl 6-cyano-2-methylnicotinate was synthesized from methyl 2-methylnicotinate following the general procedure as described for 4-isopropyl-2-pyridylmethylamine.

Sources & evidence

ORD record
ord-d8991108af4a47f787e60c7d53e5604b
Source dataset
uspto-grants-2012_10
Patent number
US08299267B2

Reaction notes

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