Methyl 6-cyano-2-methylnicotinate → Methyl 6-(aminomethyl)-2-methylpyridine-3-carboxylate

HRID 2070929Notes

Reaction equation

HRID 2070929 reaction equation
[C:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:5]([CH3:13])[N:4]=1)#[N:2].C(C1C=C(CN)C=CN=1)(C)C>>[NH2:2][CH2:1][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:5]([CH3:13])[N:4]=1

Participants

3

Reactant 2

HCID 55253164Methyl 6-cyano-2-methylnicotinateHCID 59569820(2-Isopropylpyridin-4-yl)methanamine

Product 1

HCID 59569936Methyl 6-(aminomethyl)-2-methylpyridine-3-carboxylate

Procedure

methyl 6-(aminomethyl)-2-methylnicotinate was synthesized from methyl 6-cyano-2-methylnicotinate following the general procedure as described for 2-isopropyl-4-pyridylmethylamine.

Sources & evidence

ORD record
ord-3a905e998d024eec87b214273a9fc72e
Source dataset
uspto-grants-2012_10
Patent number
US08299267B2

Reaction notes

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