Hydrochloric Acid → HCID 59569716, compound

Participants

Reaction Steps

To a solution of crude (2,6-dimethyl-5-(prop-1-en-2-yl)pyridin-3-yl)methanamine and 120 mg (0.505 mmol) of CoCl2.6H2O in 5 mL of EtOH at 50° C. was added 115 mg of NaBH4 in 2 portions. After 2 h, 5N HCl was added to a pH=1 and stirring was continued until the bubbling ceased. The mixture was concentrated, and NH4OH was added to pH=9. Some water was added, and the aqueous layer was extracted with the extract of (40 mL CHCl3: 5 mL MeOH: 5 mL H2O). The combined extracts were dried over Na2SO4, filtered, and concentrated to give the crude (5-isopropyl-2,6-dimethylpyridin-3-yl)methanamine which was used without further purification.

Provenance & Evidence