(4-Isopropylpyridin-2-yl)methanamine → 6-Methyl-5-(methylsulfonylmethyl)picolinonitrile

HRID 2070950Notes

Reaction equation

HRID 2070950 reaction equation
[CH3:1][C:2]1[C:7]([CH2:8][S:9]([CH3:12])(=[O:11])=[O:10])=[CH:6][CH:5]=[CH:4][N+:3]=1[O-].C(C1C=C[N:20]=[C:19](CN)C=1)(C)C>>[CH3:1][C:2]1[N:3]=[C:4]([C:19]#[N:20])[CH:5]=[CH:6][C:7]=1[CH2:8][S:9]([CH3:12])(=[O:11])=[O:10]

Participants

3

Reactant 2

HCID 59135389(4-Isopropylpyridin-2-yl)methanamineHCID 686697642-methyl-3-(methylsulfonylmethyl)pyridine N-oxide

Product 1

HCID 686710426-Methyl-5-(methylsulfonylmethyl)picolinonitrile

Procedure

6-methyl-5-(methylsulfonylmethyl)picolinonitrile was synthesized from 2-methyl-3-(methylsulfonylmethyl)pyridine N-oxide following the general procedure as described for the 4-isopropyl-2-pyridylmethylamine.

Sources & evidence

ORD record
ord-daa409d4557a48b2b93319c73e90e129
Source dataset
uspto-grants-2012_10
Patent number
US08299267B2

Reaction notes

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