Hydrochloric Acid → HCID 59569764, compound

Participants

Reaction Steps

A solution of tert-butyl 3-(benzyloxy)-5-isopropylbenzylcarbamate and 15.0 mL of 1.25 M HCl in MeOH was stirred at r.t. for 3.5 h. The solution was concentrated, and saturated NaHCO3 was added to a pH=7-8. The aqueous layer was extracted with the extract of (40 mL CHCl3: 5 mL MeOH: 5 mL H2O) (2×). The combined extracts were dried over Na2SO4, filtered, and concentrated to give 221 mg of crude (3-(benzyloxy)-5-isopropylphenyl)methanamine which was used for the next reaction without further purification.

Provenance & Evidence