反应详情

To a stirred solution of LiAlH4 (114 mg, 3.6 mmol) in ether at 0° C. was added 3-(2-methyl-1,3-dioxolan-2-yl)benzonitrile (0.57 g, 3.0 mmol). The reaction mixture was stirred for 4 h and quenched with H2O (0.2 mL), 20% NaOH (0.2 mL), brine (0.6 mL). The resulting mixture was stirred for 1 h and filtered over celite and concentrated. The residue was purified by column chromatography (10% MeOH in CHCl3) to provide (3-(2-methyl-1,3-dioxolan-2-yl)phenyl)methanamine (334 mg, 57%).

1. customquenched with H2O (0.2 mL), 20% NaOH (0.2 mL), brine (0.6 mL)
2. stirringThe resulting mixture was stirred for 1 h
3. filtrationfiltered over celite and
4. concentrationconcentrated
5. customThe residue was purified by column chromatography (10% MeOH in CHCl3)