HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2071032Generated: October 31, 2026
Benzyl Bromide → Dimethyl 5-bentyloxy-isophthalate
https://huagongshe.com/reaction/2071032
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,3-Benzenedicarboxylic acid, 5-hydroxy-, 1,3-dimethyl ester | HCID 83065 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Dimethyl 5-bentyloxy-isophthalate | HCID 7643390 | 93.3% |
Reaction Steps
A mixture of 1.98 g (9.42 mmol) of dimethyl 5-hydroxyisophthalate 3.0 g (21.7 mmol) of K2CO3 and 1.8 mL (15.1 mmol) of BnBr in 30 mL of DMF was heated at 60° C. for 18 h. After the mixture was filtered through cotton, water and CHCl3 were added. The organic layer was washed with water and brine, dried over Na2SO4, filtered, and concentrated. Purification by flash silica gel chromatography (15% EtOAc/hexanes) provided the 2.64 g of dimethyl 5-(benzyloxy)isophthalate as a colorless solid in 93% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08299267B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-a644c0de062248dbb7f3f2638b159b8a |
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| Source note | uspto-grants-2012_10 |
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