HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert - butyl (3 - cyanobenzyl)carbaMate → Benzonitrile, 3-(aminomethyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert - butyl (3 - cyanobenzyl)carbaMate | HCID 62313508 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | Benzonitrile, 3-(aminomethyl)- | HCID 457594 | — |
Reaction Steps
To tert-butyl 3-cyanobenzylcarbamate in CH2Cl2 (10 ml), TFA (3 ml) was added. After 1 h, volatiles were removed on a rotavap under reduced pressure. Crude residue 3-(aminomethyl)benzonitrile was dissolved in water, basified with 2N NaOH and extracted with CHCl3 (100 ml) and used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299267B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-649b53764989433388bac4e75482b71c |
| Source note | uspto-grants-2012_10 |