Hydrochloric Acid → HCID 59569874, compound

Participants

Reaction Steps

To a stirring solution of crude N-(3-(aminomethyl)-5-(prop-1-en-2-yl)phenyl)-N-methylmethanesulfonamide and 68.3 mg (0.2871 mmol) of CoCl2.6H2O in 3 mL of EtOH and 1 mL of THF at 50° C. was added 0.169 g of NaBH4 in 2 portions. After the mixture was stirred for about 3.5 h, 5 N HCl was added to a pH=1. The mixture was concentrated and (28-30) % NH4OH solution was added to pH=8. The aqueous layer was extracted with the extract of (40 mL of CHCl3: 5 mL of H2O: 5 mL of MeOH) (3×). The combined extracts were dried over Na2SO4, filtered, and concentrated. N-(3-(aminomethyl)-5-isopropylphenyl)-N-methylmethanesulfonamide was used in the next reaction without further purification.

Provenance & Evidence