Sodium Hydroxide → HCID 68670358, compound

Participants

Reaction Steps

To a solution of 901 mg (2.73 mmol) of diethyl 5-(methylsulfonamidomethyl)isophthalate in 10 mL of THF and 10 mL of MeOH was added 115 mg of NaOH in 2.7 mL of H2O. After the solution was stirred at r.t. for 50 h, the solution was concentrated, and H2O and CHCl3 were added. The aqueous layer was acidified to pH=1-2 with 1N HCl and extracted with the extract of (40 mL of CHCl3: 5 mL of MeOH, and 5 mL of H2O) several times. The combined extracts were dried over Na2SO4, filtered, and concentrated to give crude 3-(methoxycarbonyl)-5-(methylsulfonamidomethyl)benzoic acid which was used without further purification.

Provenance & Evidence