Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 3-Formyl-5-(prop-1-en-2-yl)benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3-Bromo-5-formylbenzonitrile | HCID 53425523 | — |
| 반응물 | HCID 178456118 | HCID 178456118 | — |
| 촉매 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 3-Formyl-5-(prop-1-en-2-yl)benzonitrile | HCID 59569691 | — |
반응 단계
To 3-bromo-5-formylbenzonitrile (420 mg, 2 mmol), isopropenyl potassium trifluoroborate (296 mg, 2 mmol) and triethyl amine (0.42 ml) in 2-propanol and water (20 ml) in 2:1 ratio, PdCl2(dppf) (65 mg, 0.08 mmol) was added and the reaction mixture was refluxed for 5 h. Then the reaction mixture was cooled, diluted with ether, washed with water, brine and dried. Crude residue was column chromatographed (60% ethylacetate: 40% hexane) to yield a white solid of 3-formyl-5-(prop-1-en-2-yl)benzonitrile.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08299267B2 |
| 출처 데이터셋 | uspto-grants-2012_10 |
| ORD ID | ord-4c7b8b85db8b437bad19a7e9ccc9bbaa |
| 출처 메모 | uspto-grants-2012_10 |