HCID 68670686, compound → HCID 68671840, compound

HRID 2071094Notes

Reaction equation

HRID 2071094 reaction equation
[CH3:1][O:2][CH:3]([O:17][CH3:18])[C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[C:6]([N+:14]([O-])=O)[CH:5]=1>C(O)C.[Pd]>[CH3:18][O:17][CH:3]([O:2][CH3:1])[C:4]1[CH:5]=[C:6]([CH:7]=[C:8]([C:10]([F:11])([F:12])[F:13])[CH:9]=1)[NH2:14]

Participants

4

Reactant 1

HCID 68670686HCID 68670686, compound

Product 1

HCID 68671840HCID 68671840, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 23938PalladiumSolvent

Procedure

To 1-(dimethoxymethyl)-3-nitro-5-(trifluoromethyl)benzene (1.9 gm, 7.6 mmol) in ethanol (20 ml), 10% Pd/C (200 m) was added, stirred under balloon pressure for 5 h. Then the reaction mixture was filtered and volatile were removed under vacuum to provide 3-(dimethoxymethyl)-5-(trifluoromethyl)aniline.

Workup

  1. filtrationThen the reaction mixture was filtered
  2. customvolatile were removed under vacuum

Sources & evidence

ORD record
ord-1888225ab14f4abdad6452b4a03dd3c2
Source dataset
uspto-grants-2012_10
Patent number
US08299267B2

Reaction notes

Loading…