Hydrochloric Acid → HCID 57513083, compound

Participants

Reaction Steps

Methyl thiazole-D-oxaproline (R)-4-(4-methylthiazol-2-yl)oxazolidine was made from (R)-2-amino-3-hydroxypropanoic acid (Aldrich), following similar procedure described for the synthesis of (R)-4-methyl-2-(thiazolidin-4-yl)thiazole. The intermediate (R)-tert-butyl 4-(4-methylthiazol-2-yl)oxazolidine-3-carboxylate was deprotected using 4N HCl in 1,4-dioxane (20 min) and the desired product was used for the next step without further purification.

Provenance & Evidence