HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Benzenedicarboxylic acid, 5-bromo-, 1,3-dimethyl ester → HCID 59569886, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Benzenedicarboxylic acid, 5-bromo-, 1,3-dimethyl ester | HCID 103954 | — |
| Reactant | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | HCID 2774010 | — |
| Product | HCID 59569886 | HCID 59569886 | — |
Reaction Steps
Following standard cross coupling procedure described herein, dimethy 5-bromoisophthalate (623 mg, 2.3 mmol) and 4-pyrazoleboronic acid pinacol ester (443 mg, 2.3 mmol) were reacted. The resulting aqueous layer was acidified to pH 5 and extracted with EtOAc to provide 5-(1H-pyrazol-4-yl)isophthalic acid as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299267B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-609343aa751f4ed480dc26ca56b535d6 |
| Source note | uspto-grants-2012_10 |