1,2-Ethanediamine, N1,N1,N2-trimethyl- → 4-(3,5-Dichloropyridin-4-ylamino)-8-(5-((2-(dimethylamino)ethyl)(methyl)amino)pentyloxy)-7-methoxy-2H-chromen-2-one

Participants

Reaction Steps

The title compound was prepared from N1,N1,N2-trimethylethane-1,2-diamine and 8-(5-bromopentyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one (Example 28) following the procedure outlined in Example 52. 1H NMR (400 MHz, DMSO-d6): δ 8.57 (s, 2H), 7.85 (d, 1H), 7.05 (d, 1H), 4.23 (br s, 1H), 3.96 (t, 2H), 3.87 (s, 3H), 2.65 (m, 4H), 2.55 (m, 2H), 2.34 (s, 6H), 2.31 (s, 3H), 1.69 (m, 2H), 1.51 (m, 4H); MS (ESI): 523.0.

Provenance & Evidence