HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2071216Generated: October 27, 2026
Chloroacetaldehyde → 2-(2-Methyl-5-trifluoromethylanilino)acetaldehyde
https://huagongshe.com/reaction/2071216
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chloroacetaldehyde | HCID 33 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-Methyl-5-(trifluoromethyl)aniline | HCID 2735933 | — |
| Product | 2-(2-Methyl-5-trifluoromethylanilino)acetaldehyde | HCID 21412827 | — |
Reaction Steps
2-Methyl-5-trifluoromethylaniline (0.3 mole), the dimethyl acetal of 2-chloroacetaldehyde (0.3 mole) and sodium carbonate (20 grams) are charged into a glass reaction flask equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture is heated to about 150° C. for a period of about 8 hours. After this time the mixture is filtered and the filtrate is distilled to yield the desired product the dimethyl acetal of 2-(2-methyl-5-trifluoromethylanilino)acetaldehyde.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04046554 |
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| Source dataset | uspto-grants-1977_09 |
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| ORD ID | ord-bff56277c1324a1bbdc33850d7eb1192 |
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| Source note | uspto-grants-1977_09 |
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