反应详情

A 5 gram sample of the recrystallized hydrochloride was dissolved in 50 mls. of water and a 4% aqueous solution of sodium hydroxide was added thereto until the mixture became alkaline. The solid which precipitated was separated by filtration, washed with water, and dried to obtain 3.2 grams of the free base, m.p. 163°-167° C. Recrystallization of the crude free base from a mixture of benzene and hexane gave 1.0 gram of analytically pure free base, m.p. 164°-166° C.

1. customThe solid which precipitated
2. customwas separated by filtration
3. washwashed with water
4. customdried