Isopropylamine → HCID 21413140, compound

Participants

Reaction Steps

To 22 g of (3-phenyl-1,4-benzodioxan-2-yl)-carboxylic acid in 300 cc of anhydrous benzene are added 18.1 g of PCl5 in portions with cooling. After 2 hours the reaction mixture is added to a cold solution of isopropylamine in anhydrous benzene. After stirring for 2 hours, the product is poured onto ice. The organic phase is separated, washed with H2O and finally dried over Na2SO4. The solvent is removed under vacuum. The residue is crystallised from isopropyl alcohol, m.p. = 196°-8°.

Provenance & Evidence