HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-[2-(2,6-Dichlorophenyl)ethyl]-4-benzamidopiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-4-Piperidylbenzamide | HCID 118120 | — |
| Reactant | 2-(2-Bromoethyl)-1,3-dichlorobenzene | HCID 13480195 | — |
| Product | 1-[2-(2,6-Dichlorophenyl)ethyl]-4-benzamidopiperidine | HCID 21413271 | 41.1% |
Reaction Steps
2-(2,6-Dichlorophenyl)ethyl bromide (674 mg.) was reacted with 4-benzamidopiperidine (547 mg.) in the presence of anhydrous potassium carbonate (736 mg.) following the procedure of Example 12 to give the title compound as the hydrochloride (412 mg.) m.p. 285.7° C. after crystallisation from ethanolic hydrogen chloride and ether. (Found: C, 58.0; H, 5.6; N, 6.7. C20 22Cl2N2O. HCl requires C, 58.05; H, 5.6; N, 6.8%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04046767 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-44d00885baaf4762b5d4c848f0f10839 |
| Source note | uspto-grants-1977_09 |