Water → HCID 21413415, compound

HRID 2071295Notes

Reaction equation

HRID 2071295 reaction equation
[CH3:1][C:2]1[NH:3][CH:4]=[CH:5][N:6]=1.[OH2:7].[Cl:8][C:9]1[CH:10]=[C:11]([N:16]=[C:17]=O)[CH:12]=[CH:13][C:14]=1[Cl:15]>C1(C)C=CC=CC=1>[Cl:8][C:9]1[CH:10]=[C:11]([N:16]2[CH:17]=[C:5]([C:4](=[O:7])[NH2:3])[N:6]=[C:2]2[CH3:1])[CH:12]=[CH:13][C:14]=1[Cl:15]

Participants

5

Reactant 3

HCID 962WaterHCID 76073,4-Dichlorophenyl isocyanateHCID 127492-Methylimidazole

Product 1

HCID 21413415HCID 21413415, compoundYield 81.5%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 8.61 g. (0.105 mol.) of 2-methylimidazole in 60 ml. of water is added dropwise to the stirred solution of 18.8 g. (0.1 mol.) of 3,4-dichlorophenyl-isocyanate in 120 ml. of toluene at 10° to 12° C. under cooling. The reaction mixture is stirred at room temperature for one hour. The separated product is filtered off, washed and dried. 22.0 g. (81.5%) of 1-(3,4-dichlorophenyl)-carbamoyl-2-methylimidazole are obtained; m.p.: 140° C.

Workup

  1. filtrationThe separated product is filtered off
  2. washwashed
  3. customdried

Sources & evidence

ORD record
ord-ec911edf4ffd4826b9ff195c1cbadb4e
Source dataset
uspto-grants-1977_09
Patent number
US04046773

Reaction notes

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