HCID 21413360, compound → HCID 21413341, compound

Participants

Reaction Steps

To a solution of 0.396 g. of 4-acetoxy-8-chloro-6-phenyl-4H-s-triazolo[1,5-a][1,4]benzodiazepine-2-carboxamide in 10 ml. of methanol are added two drops of concentrated sulfuric acid, and the mixture was refluxed for 5 minutes, followed by evaporation of methanol. The residue is neutralized with saturated aqueous sodium bicarbonate solution and the precipitated crystals are collected by filtration, washed with water and dried to obtain 8-chloro-4-methoxy-6-phenyl-4H-s-triazolo[1,5-a][1,4]benzodiazepine-2-carboxamide as crystals. Recrystallization from a mixture of chloroform and methanol yields colorless prisms (1/3 hydrate) melting at 264° to 267° C.

Provenance & Evidence