Pyridine → HCID 21413360, compound

HRID 2071303Notes

Reaction equation

HRID 2071303 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[N:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:10]3[CH:9]([OH:18])[N:8]=[C:7]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:6]=2[CH:25]=1.N1C=CC=CC=1.[C:32](OC(=O)C)(=[O:34])[CH3:33]>O>[C:32]([O:18][CH:9]1[N:8]=[C:7]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:6]2[CH:25]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=2[N:11]2[N:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:10]12)(=[O:34])[CH3:33]

Participants

5

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 21413348HCID 21413348, compound

Product 1

HCID 21413360HCID 21413360, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 0.38 g. of 8-chloro-4-hydroxy-6-phenyl-4H-s-triazolo[1,5-a][1,4]benzodiazepine-2-carboxamide (3/2 hydrate) in 5 ml. of pyridine is added 0.2 ml. of acetic anhydride and the mixture is left to stand at room temperature for 2 hours, followed by addition of water. The precipitated crystals are collected by filtration to yield 4-acetoxy-8-chloro-6-phenyl-4H-s-triazolo[1,5-a][1,4]-benzodiazepine-2-carboxamide as crystals. This product is identical with the product in Example 1 with respect to melting point and infrared absorption spectrum.

Workup

  1. filtrationThe precipitated crystals are collected by filtration

Sources & evidence

ORD record
ord-6d7c930d0edf41c1a2a953ae65fd1181
Source dataset
uspto-grants-1977_09
Patent number
US04046772

Reaction notes

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