HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 10-(5,5-Dimethyl-1-pyrrolin-2-YL)-2-(trifluoromethyl)phenoxazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 2-Trifluoromethylphenoxazine | HCID 10467321 | — |
| Reactant | 5,5-Dimethylpyrrolidin-2-one | HCID 11126210 | — |
| Product | 10-(5,5-Dimethyl-1-pyrrolin-2-YL)-2-(trifluoromethyl)phenoxazine | HCID 22754268 | — |
Reaction Steps
Reaction of 2-(trifluoromethyl)phenoxazine, 5,5-dimethyl-2-pyrrolidinone and phosphorus oxychloride according to the procedure of Example 1 provides the free base 10-(5,5-DIMETHYL-1-PYRROLIN-2-YL)-2-(TRIFLUOROMETHYL)PHENOXAZINE, m.p. 64°-67° C. Conversion of the free base to the hydrochloride salt affords 10-(5,5-DIMETHYL-1-PYRROLIN-2-YL)-2-(TRIFLUOROMETHYL)PHENOXAZINE HYDROCHLORIDE, m.p. 204.5°-207.5° C. (dec.) (corr.), in a 30% overall yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04046891 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-0ccd5f8dd420421594959db22133c3fe |
| Source note | uspto-grants-1977_09 |