HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazomethane → HCID 21408257, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | 5-Thiazolecarboxylic acid, 2-ethyl- | HCID 207755 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 21408257 | HCID 21408257 | — |
Reaction Steps
A solution of diazomethane in methylene chloride was added to a suspension of 10.45 g of 2-ethyl-thiazole-5-carboxylic acid in 30 ml of methylene chloride until efferversence stopped and the methylene chloride was distilled. The oily residue was chromatographed over silica and was eluted with a 1:1 mixture of benzene-ethyl acetate to obtain 11.3 g of methyl 2-ethyl-thiazole-5-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04046902 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-eb51efeb4aee4a3ea3665b059cc5fdc1 |
| Source note | uspto-grants-1977_09 |