Triethylamine → Bis(eta-cyclopentadienyl) iron

Participants

Reaction Conditions

Reaction Steps

1,1'-ferrocenediacetyl chloride (2 g, 0.006 m) in dichloromethane (10 cm3) added dropwise to mixture of 6-aminopenicillanic acid (2.6 g, 0.012 m) and triethylamine (2.42 g, 0.024 m) in dichloromethane (30 cm3) at 0° C. Mixture stirred for 15 minutes at 0° C. and 1 hour at 15° C. Procedure as for previous penicillins. Yield of sodium salt of 1,1'-bis(6-acetamido-penicillanic acid)ferrocene was 2.63 g (59%).

Provenance & Evidence