HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 3-Methyl-4-[(2-aminoethyl)thiomethyl]isothiazole hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Cysteamine Hydrochloride | HCID 9082 | — |
| Reactant | (3-Methyl-1,2-thiazol-4-YL)methanol | HCID 20550175 | — |
| Product | 3-Methyl-4-[(2-aminoethyl)thiomethyl]isothiazole hydrobromide | HCID 20550132 | — |
Reaction Steps
Reacting 4-hydroxymethyl-3-methylisothiazole (3.0 g) with cysteamine hydrochloride (2.8 g) in 48% aqueous hydrobromic acid (50 ml) by the procedure of Example 42(ii) gives 3-methyl-4-[(2-aminoethyl)thiomethyl]isothiazole hydrobromide. The base is obtained by basifying with aqueous potassium carbonate, extracting with chloroform, drying the extracts over magnesium sulphate and concentrating. Using the amine (5.0 g) as the starting material in the procedure of Example 72(ii) yields the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04046907 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-d534ffbbe60643baa8159392788f3a19 |
| Source note | uspto-grants-1977_09 |