HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Ethyl-2-fluoro-N-(2-hydroxyphenyl)benzamide → 2-(4-Ethyl-2-fluorophenyl)-1,3-benzoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Ethyl-2-fluoro-N-(2-hydroxyphenyl)benzamide | HCID 21413807 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-(4-Ethyl-2-fluorophenyl)-1,3-benzoxazole | HCID 20230225 | — |
Reaction Steps
4-Ethyl-2-fluoro-2'-hydroxybenzanilide (29.0 gm.) is heated for 40 minutes in a Wood's metal bath at 240° C. The reaction mixture is then cooled, taken up in chloroform and the chloroform solution treated with carbon, dried over magnesium sulfate and concentrated in vacuo to give 2-(4-ethyl-2-fluorophenyl)benzoxazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04046905 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-d1b243fc09db410e9e471247aadb9f9e |
| Source note | uspto-grants-1977_09 |