反应详情

Conversion of the hydrochloride salt of 2-imino-1-methylpyrrolidine (6.73 g.; 0.05 mole) to the free base (4.9 g. assuming 100% conversion) is carried out in the usual manner. After drying over K2CO3, the benzene layer is stirred, and 6.66 g. (0.05 mole) of m-tolylisocyanate is added (solid forms). The reaction mixture is stirred at room temperature overnight. The solid is collected, m.p. = 148°-149° C. The benzene filtrate, after removal of solvent, yields a further crop of solid material, m.p. 137°-142° C. Recrystallizations of the combined solids from acetone gives the pure product, 1-m-methylphenyl-3-(1-methyl-2-pyrrolidylidene)urea, m.p. = 149°-151° C.

1. dry with materialAfter drying over K2CO3
2. stirringThe reaction mixture is stirred at room temperature overnight
3. customThe solid is collected
4. customThe benzene filtrate, after removal of solvent
5. customyields a further crop of solid material, m.p. 137°-142° C
6. customRecrystallizations of the combined solids from acetone