反应详情

The cyclohexylsulfamic acid salt of 1-n-butyl-2-iminopyrrolidine (15.97 g.; 0.05 mole) is converted to free base (7.01 g.; 0.05 mole) in the usual manner. After drying over K2CO3, the benzene solution is filtered through diatomaceous earth and 7.36 g. (0.05 mole) of 2,6-dimethylphenylisocyanate is added. The reaction mixture is stirred at room temperature for 31/2 hours and then evaporated to dryness in vacuo leaving an oily residue which crystallizes on cooling. Recrystallization from ethylacetate yields the pure product, 1-(1-n-butyl-2-pyrrolidylidene)-3-(2,6-dimethylphenyl)urea, m.p.=93°-95° C.

1. dry with materialAfter drying over K2CO3
2. filtrationthe benzene solution is filtered through diatomaceous earth and 7.36 g
3. customevaporated to dryness in vacuo
4. customleaving an oily residue which
5. customcrystallizes
6. temperatureon cooling
7. customRecrystallization from ethylacetate