反应详情

The fluoroborate salt of 1-benzyl-2-iminopyrrolidine (6.55 g; 0.025 mole) is converted to the free base (4.36 g.; 0.025 mole) in the usual manner. After drying over K2CO3, the benzene solution is filtered through diatomaceous earth and 4.29 g.; (0.025 mole) of 3-chloro-4-fluorophenylisocyanate is added. The reaction mixture is stirred at room temperature for 1 hour and then evaporated to dryness in vacuo to give a soild residue. Recrystallizations from acetone-ether yields the pure product, 1-(1-benzyl-2-pyrrolidylidene)-3-(3-chloro-4-fluorophenyl)urea, m.p. - 131°-132° C.

1. dry with materialAfter drying over K2CO3
2. filtrationthe benzene solution is filtered through diatomaceous earth and 4.29 g
3. customevaporated to dryness in vacuo
4. customto give a soild residue
5. customRecrystallizations from acetone-ether