4-(Benzyloxy)phenyl isocyanate → 1-(4-Benzyloxyphenyl)-3-(1-methyl-2-piperidylidene)urea

HRID 2071526Notes

Reaction equation

HRID 2071526 reaction equation
[NH:1]=[C:2]1[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[CH3:8].[CH2:9]([O:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]=[C:24]=[O:25])=[CH:19][CH:18]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C1C=CC=CC=1>[CH2:9]([O:16][C:17]1[CH:22]=[CH:21][C:20]([NH:23][C:24]([N:1]=[C:2]2[CH2:7][CH2:6][CH2:5][CH2:4][N:3]2[CH3:8])=[O:25])=[CH:19][CH:18]=1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 2562684-(Benzyloxy)phenyl isocyanateHCID 124490281-Methylpiperidin-2-imine

Product 1

HCID 539156231-(4-Benzyloxyphenyl)-3-(1-methyl-2-piperidylidene)urea

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

The hydrochloride salt of 2-imino-1-methylpiperidine (7.43 g.; 0.05 mole) is converted to the free base in benzene in the usual manner. After drying over K2CO3 and filtering, a benzene solution of 0.05 mole of p-benzyloxyphenylisocyanate is added dropwise with stirring. After addition is complete, further stirring is continued for about 6 hours at room temperature. The benzene is evaporated in vacuo and the solid residue is recrystallized from methanol to give the product 1-(4-benzyloxyphenyl)-3-(1-methyl-2-piperidylidene)urea.

Workup

  1. dry with materialAfter drying over K2CO3
  2. filtrationfiltering
  3. additionAfter addition
  4. stirringfurther stirring
  5. customThe benzene is evaporated in vacuo
  6. customthe solid residue is recrystallized from methanol

Sources & evidence

ORD record
ord-9f4b2f4a3d344565b879d4c334bb4c54
Source dataset
uspto-grants-1977_09
Patent number
US04046909

Reaction notes

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