HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-Acetylpiperidine-4-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-Acetylpiperidine-4-carboxylic acid | HCID 117255 | — |
| Product | 1-Acetylpiperidine-4-carbonyl chloride | HCID 100950 | — |
Reaction Steps
A sample of 65.4 g of 1-acetylisonipecotic acid is dissolved in 400 ml of thionyl chloride. The acid chloride precipitates from solution and one liter of petroleum ether is added. The mixture is filtered, the solid residue is washed several times with petroleum ether and dried, giving 1-acetylisonipecotoyl chloride as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04046900 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-c7c0f28bd5a84af2b7b1e41858acc3e8 |
| Source note | uspto-grants-1977_09 |