HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 13180295, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-(2-Bromoethyl)indole | HCID 76924 | — |
| Reactant | ([1,1'-Biphenyl]-4-yl)(piperidin-4-yl)methanone | HCID 20311704 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 13180295 | HCID 13180295 | — |
Reaction Steps
A solution of 10.4 g of 4-(4-phenylbenzoyl)piperidine, 8.8 g of 3-(2-bromoethyl)indole and 4.5 g of triethylamine in 300 ml of dimethylformamide is treated according to the manipulative procedures outlined in Example 3(b) to produce 3-{2-[4-(4-phenylbenzoyl)piperidyl]ethyl}indole. The indole is recrystallized twice from an ethanol-water mixture (one charcoal treatment), thrice from a pyridine-water mixture, and twice from an acetone-water mixture to give the product, mp 189°-192° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04046900 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-20102b5ff76d4c93bc377c2ba820ea87 |
| Source note | uspto-grants-1977_09 |