Benzaldehyde → HCID 21411641, compound

Participants

Reaction Steps

A mixture of 3.23 g (0.013 mole) of N-(2,2,2-trifluoroethyl)-N-(p-methoxyphenyl)urea, 1.6 g (0.015 mole) of benzaldehyde, 5.3 g (0.039 mole) of anhydrous zinc chloride, and 65 ml of xylene was stirred for a while and then heated under reflux for 15 hours, removing the water formed azeotropically. Thereafter, 20 ml of 1N-hydrochloric acid was added to the reaction mixture and the mixture was stirred for a while. The organic layer was separated from the reaction mixture, washed with water, dried over anhydrous sodium sulfate, and evaporated under reduced pressure. The resulting residue was treated with isopropyl alcohol to give 2.71 g (62%) of 1-(2,2,2-trifluoroethyl)-4-phenyl-6-methoxy-3,4-dihydro-2(1H)-quinazolinone, m.p. 168°-169° C.

Provenance & Evidence