Dimethylhydantoin → 3-(6-Chloro-n-hexyl)-5,5-dimethyl-hydantoin

Participants

Reaction Steps

128 g of 5,5-dimethyl-hydantoin (1.0 mol), 69 g of anhydrous potassium carbonate (0.5 mol) and 775 g of 1,6-dichlorohexane are reacted at 132°-150° C internal temperature (external temperature 160° C) and the resulting water of reaction is removed continuously by azeotropic circulatory distillation. After 6 hours 25 minutes, the reaction is complete and the reaction mixture is filtered hot to remove the potassium chloride formed. The filtrate is concentrated on a rotary evaporator and dried to constant weight at 100° C and 10-1 mm Hg.

Provenance & Evidence