HCID 53980569, compound → HCID 53745082, compound

Participants

Reaction Steps

IV (1.77 g, 0.00500 mole), methanol (50 ml), and Raney nickel (1 g) were shaken under hydrogen at a pressure of 70 atmospheres for 24 hours at room temperature. After filtration, the solvent was removed from a water bath (60° C, 10 mm Hg). Ether (50 ml) was added to the residue, and the turbid, colourless solution was filtered. The ethereal solution was evaporated to dryness from a water bath (60° C, 10 mm Hg). The residual clear, colourless oil (1.90 g) was distilled under reduced pressure to give 1.69 g (95%) of VI as a colourless oil, b0.05 160°-172° C, nD25 1.4625.

Provenance & Evidence