Potassium Carbonate → HCID 21412027, compound

Participants

Reaction Steps

VI (1.78 g, 0.00500 mole), methanol (20 ml), and 20% aqueous potassium carbonate (10 ml) were stirred and heated under reflux for 90 minutes. The methanol was removed from a water bath (60° C, 100 mm Hg). The residue was diluted with water (25 ml) and washed with ether (25 ml). The resulting clear solution was acidified to pH 5-6 with acetic acid. An emulsion was formed, which was extracted with ether (25 + 25 ml). The combined ethereal extracts were dried over sodium sulfate and evaporated from a water bath (60° C, 1 mm Hg) to give 1.62 g (95%) of VII as a light yellowish oil, nD25 1.4682.

Provenance & Evidence