Methanol → HCID 54544527, compound

Participants

Reaction Steps

XI (1.78 g, 0.00500 mole), methanol (25 ml), and ethyl ether-borontrifluoride complex (0.1 ml) were stirred and heated under reflux for 1 hour. After cooling, the reaction mixture was poured into ice-water (200 ml) and extracted with ether (50 + 50 + 25 ml). The combined ethereal extracts were washed with cold 2% aqueous sodium hydrogen carbonate (50 ml) and water (50 ml). The ethereal solution was dried over sodium sulfate and evaporated to dryness from a water bath (60° C, 10 mm Hg). The residual yellowish oil (1.95 g) was distilled under reduced pressure to give 1.82 g (98%) of XII as a colourless oil, b0.03 160°-170° C, nD25 1.4625.

Provenance & Evidence