Chlorotrimethylsilane → 5-bromo-N4-cyclobutyl-N2-(1H-indazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

HRID 207167Notes

Reaction equation

HRID 207167 reaction equation
[Br:1][c:2]1[cH:3][nH:4][c:5]2[n:6][c:7]([Cl:16])[n:8][c:9]([NH:11][CH:12]3[CH2:13][CH2:14][CH2:15]3)[c:10]12.[CH3:27][Si:28]([Cl:29])([CH3:30])[CH3:31].[NH2:17][c:18]1[cH:19][cH:20][c:21]2[cH:22][n:23][nH:24][c:25]2[cH:26]1>>[Br:1][c:2]1[cH:3][nH:4][c:5]2[n:6][c:7]([NH:17][c:18]3[cH:19][cH:20][c:21]4[cH:22][n:23][nH:24][c:25]4[cH:26]3)[n:8][c:9]([NH:11][CH:12]3[CH2:13][CH2:14][CH2:15]3)[c:10]12

Participants

4

Reactant 3

HCID 6397ChlorotrimethylsilaneHCID 814231H-Indazol-6-amineHCID 579903055-bromo-2-chloro-N-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Product 1

HCID 444676785-bromo-N4-cyclobutyl-N2-(1H-indazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

Sources & evidence

ORD record
ord-f7a09b1a6914433bb1b917ef99c96220
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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