反应详情

A suspension of 3.3 g. of methyl 3-chloro-1-methyl-5-(p- toluoyl)pyrrole-2-acetate (0.0108 mole) from Example II in 12 ml. of IN sodium hydroxide and 5 ml. of ethanol is refluxed for 30 min. The ethanol is evaporated from the yellow solution, and the latter is poured into dilute HCl. The precipitate is collected, air dried, and recrystallized from 2-propanol to give 3-chloro-1-methyl-5-(p-toluoyl) pyrrole-2-acetic acid as a white solid; m.p. 163°-164° C (dec.)

1. additionA suspension of 3.3 g
2. customThe ethanol is evaporated from the yellow solution
3. additionthe latter is poured into dilute HCl
4. customThe precipitate is collected
5. customair dried
6. customrecrystallized from 2-propanol