HCID 21411820, compound → HCID 21411959, compound

HRID 2071685Notes

Reaction equation

HRID 2071685 reaction equation
[Br:1][C:2]1[C:3]([C:23]([O:25]CC)=[O:24])=[C:4]([CH2:17][C:18]([O:20]CC)=[O:19])[N:5]([CH3:16])[C:6]=1[C:7](=[O:15])[C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1>[OH-].[Na+]>[Br:1][C:2]1[C:3]([C:23]([OH:25])=[O:24])=[C:4]([CH2:17][C:18]([OH:20])=[O:19])[N:5]([CH3:16])[C:6]=1[C:7](=[O:15])[C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1

Participants

3

Reactant 1

HCID 21411820HCID 21411820, compound

Product 1

HCID 21411959HCID 21411959, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A 17.8 g. sample of ethyl 4-bromo- 5-p-chlorobenzoyl-3-ethoxycarbonyl-1-methylpyrrole-2acetate in 200 ml of 25% sodium hydroxide is stirred at 95° C. for 2 hours. It is then poured into ice-hydrochloric acid and the resulting solid 4-bromo-3-carboxy-5-p-chlorobenzoyl-1- methylpyrrole-2-acetic acid is collected and dried; m.p. 261° -263° C.

Workup

  1. customthe resulting solid 4-bromo-3-carboxy-5-p-chlorobenzoyl-1- methylpyrrole-2-acetic acid is collected
  2. customdried

Sources & evidence

ORD record
ord-56e14e9cfaf9441c8acd05b7e7808f29
Source dataset
uspto-grants-1977_09
Patent number
US04048191

Reaction notes

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