HCID 21411829, compound → HCID 21411844, compound

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Reaction Steps

A 7.2 g. sample of ethyl 4-bromo-3-carboxy-5-p- chlorobenzoyl-1-methylpyrrole-2-acetate is heated at 250° for 10 minutes under nitrogen. It is then cooled and dissolved in ether; the resulting ether solution is filtered, washed with sodium hydroxide solution, and then washed with water. After the ether is evaporated in vacuo, the residue is triturated with boiling hexane. Concentration of the hexane solution to a small volume in vacuo yields a crystalline precipitate, which is recrystallized from methanol to give ethyl 4-bromo-5-(p-chlorobenzoyl)-1-methylpyrrole-2-acetate as a white solid; m.p. 118°-120° C.

Provenance & Evidence