反应详情

To a solution of 91.0 g of 1-(pyrrol-2-ylmethylene)pyrrolidmium bromide (0.397 mole) in 1300 ml of absolute chloroform is added dropwise with stirring and ice-cooling 63.4 g of bromine (0.397mole). A solid precipitates during addition. After the reaction mixture has been stirred at room temperature for 64 hours, the solvent is evaporated in vacuo and the residue is recrystallized from 3:1 chloroform-acetonitrile to give as an off-white solid 1-(4-bromopyrrole-2-ylmethylene)pyrrolidinium bromide; m.p. 226°-228° C.

1. customA solid precipitates during addition
2. stirringAfter the reaction mixture has been stirred at room temperature for 64 hours
3. customthe solvent is evaporated in vacuo
4. customthe residue is recrystallized from 3:1 chloroform-acetonitrile