Water → HCID 21411824, compound

Participants

Reaction Steps

A suspension of 0.50 g of 4-chloro-1-methyl-5-(p-methylsulfinylbenzoyl)-pyrrole-2-acetonitrile from Example XLV is stirred and refluxed in a solution of 0.13 g sodium hydroxide in 2 ml H2O and 2 ml 95% ethanol for 2 hours. The whole is then poured into water and the resulting aqueous solution is washed with chloroform. The washed aqueous solution is then acidified to pH 1 with 3N HCl. The solid which precipitates is collected by filtration and is recrystallized from 10:1 chloroform: water to give 4-chloro-1-methyl-5-(p-methylsulfinylbenzoyl)-pyrrole-2-acetic acid as a yellow solid; m.p. 222°-223° C.

Provenance & Evidence