4-(Aminomethyl)Benzoic Acid → HCID 178511262, compound

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Reaction Steps

Trans-4-aminomethylcyclohexane-1-carboxylic acid was prepared using 30 g of p-aminomethylbenzoic acid, 3 g of 5% ruthenium supported on activated carbon and 300 ml of 14N hydrochloric acid or a 20% aqueous sodium hydroxide solution as a solvent under the conditions shown in Table 2 below. For the purposes of comparison, the results obtained by isomerizing 100% cis-4-aminomethylcyclohexane-1-carboxylic acid under the same conditions as above but without using hydrogen for reduction are also shown in Table 2.

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