4-(Aminomethyl)Benzoic Acid → HCID 178511262, compound

Participants

Reaction Steps

30 g of p-aminomethylbenzoic acid, 3 g of 5% ruthenium supported on activated carbon and 100 ml of an aqueous sodium hydroxide solution as a solvent under the conditions shown in Table 4 below were charged in an autoclave and then reacted at a temperature of 80° C, 100° C, and 150° C, respectively, under an initial hydrogen pressure of 150 kg/cm2 to obtain trans-4-aminomethylcyclohexane-1-carboxylic acid in each case. The reaction product thus obtained was in the form of the sodium salt and was converted into the free acid using an ion-exchange resin.

Provenance & Evidence