Cyanamide → HCID 108190, compound

HRID 2071725Notes

Reaction equation

HRID 2071725 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][CH2:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[CH:7]([CH2:16][CH2:17][CH2:18][N:19](C)[CH3:20])[C:6]=2[CH:22]=1.N#CN>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][CH2:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[CH:7]([CH2:16][CH2:17][CH2:18][NH:19][CH3:20])[C:6]=2[CH:22]=1

Participants

3

Reactant 2

HCID 9864CyanamideHCID 191713-(3-Chloro-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)-N,N-dimethylpropan-1-amine

Product 1

HCID 108190HCID 108190, compound

Procedure

3-Chloro-10,11-dihydro-5-(3-dimethylaminopropyl)-5H-dibenzo[a,d]cycloheptene is converted to the corresponding cyanamide by following the procedure of Example 6 A. Upon hydrolysis, according to the procedure of Example 6 B., there is obtained 3-chloro-10,11-dihydro-5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene. This may be converted to its hydrochloride salt directly by treatment with ethanolic hydrogen chloride as described in Example 6 B. After recrystallization from a mixture of isopropyl alcohol and ether, the hydrochloride salt melts at 192.5°-193.5° C., dec.

Workup

  1. customUpon hydrolysis

Sources & evidence

ORD record
ord-5c9586e1ad1a4722a6296f491062a5ec
Source dataset
uspto-grants-1977_09
Patent number
US04048223

Reaction notes

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